Fitmunk provides a framework for fitting conformations on a fixed backbone into electron density.

Current Fitmunk applications can assist in protein model building, refinement and validation.

Conformation recognition

Conformation recogniton

Primary application of Fitmunk is a recognition of side chain conformations. Fitmunk can correctly recognize conformation at almost 100% of positions.

Sequence recognition

Sequence recognition

Fitmunk can recognize protein sequence from electron density maps without prior information about correct sequence. It can also assign a target sequence to a model. De novo sequence recognition is currently limited to topology recognition (e.g. no differentiation between ASN and ASP)

Alternative conformations

Alternative conformations

Fitmunk can model alternative conformations of amino acid sidechains. This feature is currently under development and the results may contain false positives

If you found Fitmunk useful in your work please cite:

Porebski PJ, Cymborowski M, Pasenkiewicz-Gierula M, Minor W (2016)
Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.
Acta Crystallogr D Struct Biol 72: 266-80.

[DOI:10.1107/S2059798315024730] [Pub Med ID: 26894674] [Pub Med Central ID: PMC4756610]